Novel pathomechanism discovered in patients with arrhythmogenic cardiomyopathy

Dr. rer. nat Sunil Yeruva and his colleagues from research group of Prof. Jens Waschke at the Institute of Vegetative Anatomy at LMU Munich were awarded the Quarterly Publication Award (QPA) 2023 of the Anatomical Society for their investigations into the pathomechanism of arrhythmogenic cardiomyopathy:

In their study, Dr. rer. nat Sunil Yeruva and his colleagues showed for the first time that IgGs from patients with arrhythmogenic cardiomyopathy (AC) exhibit catalytic activity against desmoglein-2 (DSG2) and N-cadherin (N-CAD), thus reducing the interaction of these adhesion molecules. This was accompanied by an activation of p38MAPK. In contrast, inhibition of p38MAPK restored the reduction of AC-IgG-mediated cardiomyocyte cohesion.

Sunil YeruvaKonstanze StangnerAnna JungwirthMatthias HiermaierMaria Shoykhet Daniela KugelmannMichael HertlShohei EgamiNorito IshiiHiroshi KogaTakashi HashimotoMichael WeisBritt-Maria BeckmannRuth BillerDominik SchüttlerStefan KääbJens Waschke. Catalytic antibodies in arrhythmogenic cardiomyopathy patients cleave desmoglein 2 and N-cadherin and impair cardiomyocyte cohesion. Cellular and Molecular Life Sciences (2023) 80: 203. Doi: 10.1007/s00018-023-04853-1